. . . matters is progress in medicine: building new classes of therapy to repair and reverse the known root causes of aging . The sooner these treatments arrive, the more lives will be saved
Lithgow runs the Buck lab that in 2011 showed that Thioflavin T extended lifespan in healthy nematode worms by more than 50 percent and slowed the disease process in worms engineered to mimic aspects of Alzheimer's disease
. . . Posted by Reason Loading The practice of calorie restriction is shown to slow the progression of aging and extend healthy life in most species and lineages tested to date, including non-human primates
Nonetheless, a cross-sectional Magnetic Resonance Imaging (MRI) study of healthy volunteers showed age-related declines in the volume of gray matter in association area (rather than sensory areas) of the cerebral cortex, particularly in the prefrontal cortex [ CEREBRAL CORTEX; Raz,N; 7(3):268-282 . . .
. . . increased mortality among the elderly, those affected are generally persons with chronic disease conditions and unhealthy lifestyles. There is little alteration of thermoregulation with age among the normal elderly [ JOURNAL OF APPLIED PHYSIOLOGY; Kenney;LW; 95(6):2598-2603 (2003) ]
Regulators of mitochondrial quality control differ in subcutaneous fat of metabolically healthy and unhealthy obese monkeys. Kavanagh K, Davis AT, Peters DE, LeGrand AC, Bharadwaj MS, Molina AJ. Obesity (Silver Spring) . 2017 Feb 25. doi: 10.1002/oby.21762
Ivry studies various aspects of human performance using behavioral studies in healthy and neurologically impaired populations, brain stimulation, neuroimaging , and computational modeling
. . . Because the skull provides a handy protective casing for the brain − and because removal of the brain could be damaging − it is easier to preserve the whole head rather than just the brain. The brain is easier to vitrify than other organs, especially when attention and effort is concentrated on vitrifying the brain
. . . being alive is that it gives you the opportunity to work to make things better − and the longer you are alive and healthy, the more you are likely to succeed. If the world does become a dystopian, primitivist nightmare cryonicists probably won't be reanimated at all
It would be unfortunate to want to deprive anyone the possibility of future happy, healthy life out of a need to know there is no hope. (return to contents head) (return to topic head) II-N
. . . fibrosis is a poorly understood disease, and its effects are devastating," says Nathan LeBrasseur, Ph.D., director, HealthyAging and Independent Living program, Mayo Clinic Robert and Arlene Kogod Center on Aging and senior author of this study
. . . as well as Newcastle University Institute for Ageing and The Scripps Research Institute, studied the lung tissue of healthy individuals and of persons with mild, moderate and severe idiopathic pulmonary fibrosis
. . . to the " beta sheet " molecular structure of aggregated Aß). Aß 40 Aß 42 are formed intracellularly, but exert damaging effects when transported outside of cells
PET visualization of 10 subjects with AD and 10 young, healthy controls identified all the AD patients as Aß-positive, and all of the controls as Aß-negative [ JOURNAL OF NUCLEAR MEDICINE; Joshi,AD; 53(3):378-384 (2012) ]
. . . of AD appear, to be useful diagnostic predictors, biomarkers for Aß would have to be screened-for routinely in healthy subjects
. . . neuroprotective drug candidate for preventing and treating diverse neurodegenerative pathologies, and may promote healthyaging . Introduction Various neurodegenerative conditions are associated with the progressive accumulation of damaged, dysfunctional proteins that can act as cellular toxins 1 , 2 , 3 , 4 , 5
. . . autophagy by pharmacological means may delay the incidence of such pathologies, thereby lengthening the period of healthyaging . Indeed, promoting basal levels of autophagy in Drosophila and mice significantly increases both tissue functioning and organismal survival 24 , 27 , 46
. . . bond found in hydrogen peroxide. Lipid peroxidation and free radicals can cause cancer and may accelerate aging . High rates of lung cancer among women in China have been associated with lipid peroxidized oils in fumes from cooking polyunsaturated vegetable oils in a wok [*12]
. . . sharply reducing their calorie intake is not exactly new. Laboratory research has repeatedly demonstrated the anti-aging value of calorie restriction, often called CR, in animals from nematodes to rats—with the implication that the same might be true for humans
. . . University School of Medicine in Saint Louis who also was not involved in the new work, is “ if you’re doing a healthy diet, exercising, everything good, without doing anything extreme, without making life miserable by counting every single calorie.” Rozalyn Anderson, a researcher in the Wisconsin study, does not necessarily disagree
The benefits were greater for people who were obese or otherwise unhealthy , Longo says