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  • . . . Gene ontology Molecular function • protein N-terminus binding • transcription factor activity, sequence-specific DNA binding • protein self-association • core promoter sequence-specific DNA binding • transcription regulatory region DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • protein . . .
  • . . . RNA polymerase II transcription factor binding • zinc ion binding • chromatin binding • protease binding • damaged DNA binding • protein binding • histone acetyltransferase binding • copper ion binding • protein kinase binding • DNA binding • chaperone binding • transcriptional activator activity, RNA polymerase II transcription . . .
  • . . . in the synthesis of a functional gene product such as a protein • transcription – the process of making RNA from a DNA template by RNA polymerase • transcription factor – a protein that binds to DNA and regulates gene expression by promoting or suppressing transcription • transcriptional regulation – controlling the rate of gene transcription . . .
  • . . . – the process of making RNA from a DNA template by RNA polymerase • transcription factor – a protein that binds to DNA and regulates gene expression by promoting or suppressing transcription • transcriptional regulation – controlling the rate of gene transcription for example by helping or hindering RNA polymerase binding to DNA • upregulation . . .
  • . . . External IDs OMIM: 194360 MGI: 99137 HomoloGene: 31368 GeneCards: XRCC1 Gene ontology Molecular function • damaged DNA binding • enzyme binding • protein binding • DNA ligase activity • 3' overhang single-stranded DNA endodeoxyribonuclease activity Cellular component • nucleoplasm • nuclear chromosome, telomeric region • ERCC4-ERCC1 complex • . . .
  • . . . • ERCC4-ERCC1 complex • nucleus Biological process • single strand break repair • nucleotide-excision repair, DNA gap filling • transcription-coupled nucleotide-excision repair • response to hypoxia • response to organic substance • double-strand break repair via homologous recombination • response to drug • cellular response to DNA . . .
  • DNA rearrangement causes one copy of each type of gene segment to go in any given lymphocyte, generating an enormous antibody repertoire; roughly 3×10 11 combinations are possible, although some are removed due to self reactivity.
  • Any DNA between these two gene segments is deleted. This D-J recombination is followed by the joining of one V gene segment, from a region upstream of the newly formed DJ complex, forming a rearranged VDJ gene segment
  • roderma pigmentosum ( XP ) is a rare autosomal recessive genetic disorder of DNA repair in which the ability to repair damage caused by ultraviolet (UV) light is deficient.
  • Normally, damage to DNA in epidermal cells occurs during exposure to UV light. The absorption of the high-energy light leads to the formation of pyrimidine dimers , namely cyclobutane-pyrimidine dimers and pyrimidine-6-4-pyrimidone photoproducts
  • e DNA sequence of a gene often varies from one individual to another.
  • Zygosity is a description of whether those two alleles have identical or different DNA sequences. In some cases the term "zygosity" is used in the context of a single chromosome
  • bulin-binding drugs kill cancerous cells by inhibiting microtubule dynamics, which are required for DNA segregation and therefore cell division .
  • . . . of the cytoskeleton , and function in many processes, including structural support, intracellular transport , and DNA segregation. Microtubules are assembled from dimers of α- and β-tubulin. These subunits are slightly acidic with an isoelectric point between 5.2 and 5.8. [12] Each has a molecular weight of approximately 50 kDa
  • ] Genomic and proteomic assays : Cells can be assayed for activation of stress pathways using DNA microarrays and protein chips.
  • . . . -based assays ( MTT /XTT) Green fluorescent protein Lactate dehydrogenase (LDH) Methyl violet Propidium iodide , DNA stain that can differentiate necrotic , apoptotic and normal cells
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