A growing body of clinical and experimental evidence suggests that gut microbiota may contribute to aging and influence brain disorders 4 . In particular, a new connection between gut microbiota and Parkinson’s disease has been reported in humans 5
This observation was confirmed by quantitative imaging and revealed that both young and aged GF-APPPS1 animals exhibited a 64% and 40% decrease in Iba-1 positive immunostaining, respectively (p < 0.001 for both groups) as compared to the 3.5 and 8 month-old CONVR-APPPS1 . . .
. . . on cell viability and in terms of the neutralization of these effects by dimethyl sulfoxide. FIG. 9 illustrates the process for selecting solutions for use in supercooling experiments on living systems. FIG
. . . after perfusion with VS41A and transplantation with immediate contralateral nephrectomy (Fahy, in: Advances in Anti-Aging Medicine, Vol. 1, R. M. Klatz, ed., Mary Ann Liebert, Inc., Larchmont, N.Y., pp. 249-255, 1996), but 50% survival is not sufficient
(For more on these subjects see "The Free Radical Theory of Aging" and "Mitochondria and Aging" .) Acetaldehyde which escapes immediate conversion to acetic acid can bind to cysteine, a constituent of the anti-oxidant peptide glutathione (GSH) — further compromising liver mitochondrial . . .
. . . administration to rats induces lipofuscin deposition in neurons of the hippocampus comparable to changes seen in aging [NEUROBIOLOGY OF AGING; Borges,MM; 7(5):347-355 (1986)]
. . . inhibitor of the NMDA receptor. NMDA function in the hippocampus is associated with memory formation through a process known as LTP ( Long-Term Potentiation ) . Ethanol produces a dose-dependent suppression of the magnitude of LTP [BRAIN RESEARCH 688:27-33 (1995)]. In high doses ethanol can block LTP almost entirely
A high-fat meal elevates A HREF="../lifeext/aging .html#inflame" TARGET="_blank" plasma inflammatory cytokines more than a high carbohydrate meal [ JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY; Nappo,F; 39(7):1145-1150 (2002) ].
. . . consumption. In recent decades there has been a great increase in the use of High Fructose Corn Syrup ( HFCS ) in processed foods. From 1970 to 1997 per capita consumption of HFCS increased from 0.5 pounds to 62.4 pounds in the United States [ THE AMERICAN JOURNAL OF CLINICAL NUTRITION; Elliott,SS; 76(5):911-922 (2002) ]
. . . glycates proteins , possibly including insulin receptors, thereby exacerbating insulin resistance and "accelerating aging" (diabetes is a segmental progeria ). N-acetylcysteine and taurine and can prevent induction of insulin resistance by high blood glucose [ AMERICIAN JOURNAL OF PHYSIOLOGY; Haber,CA; 285(4):E744-E753 (2003) ]
. . . by as much as 200 times. Cooking with fat allows for high temperatures and also can contribute to the oxidation process that turns glycated proteins into AGEs. High temperature cooking of meat fat produce foods with the highest AGE content [ANNALS OF THE NEW YORK ACADEMY OF SCIENCES; Uribarri,J; 1043:461-466 (2005)]
Restarting blood flow after more than about ten minutes of ischemia is typically more damaging than the ischemia itself because the ischemia sets the stage for oxygen to generate free-radicals rather than to contribute to cellular energy production [ CARDIOVASCULAR RESEARCH; Zweier,JL; 70(2):181-190 (2006) ]
. . . of lactic acid which lowers cellular pH. Cells use Na /H exchange to eliminate excess protons, but in the process accumulate excess Na which cannot be exported with the sodium pump (Na-K-ATPase) due to ATP deficiency. As a consequence cells use the Na /Ca 2 exchange, which loads cells with Ca 2
The most damaging effect of ischemia within the first hour or two is to the capacity for cerebral blood flow [BRAIN RESEARCH 81:59-74 (1974)]. Lactic acidosis causes endothelial cells to swell [ACTA NEUROPATHOLOGIA 60:232-240 (1983)]
. . . So, in the final analysis, these statements about the safety of GM products are nothing more than guess work presaging an outcome that is impossible to divine.
. . . that GM is “ safe” are not “ opinions” –they are factual statements based on hundreds of studies and the fact the process of GM technology is understood and monitored. That’s based on the scientific method of empirical research and weight of evidence
. . . GM has not arisen out of necessity. My point is, and has been stated already, GM crops are brand new. The whole process and the conduit for genetic change is brand new. The whole, incomplete scientific knowledge set of genetically modified is brand new too
. . . & Therapeutics Cognition Cognition & Emotion Cognitive Behaviour Therapy Cognitive Neuropsychology Cognitive Processing Cold Spring Harbor Perspectives in Biology Cold Spring Harbor Protocols Colloids and Surfaces A: Physicochemical and Engineering Aspects Colloids and Surfaces
. . . Human Nature (Hawthorne, N.Y.) Human Relations Hydrobiologia Ibis IEEE Software IEEE Transactions on Advanced Packaging Immunological Reviews Immunotherapy Industrial Crops and Products Infection Information Sciences Inorganica Chimica Acta Intelligence Intercultural Education Intermetallics International Journal of Antimicrobial . . .
. . . of Advertising Research Journal of Affective Disorders Journal of Aggression, Maltreatment & Trauma Journal of Aging and Physical Activity Journal of Agricultural & Food Information Journal of Agromedicine Journal of Alloys and Compounds Journal of Alternative and Complementary Medicine (New York, N.Y.) Journal of Anxiety Disorders . . .
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